The Intersect Suppression Device refers to a small black portable machine, first seen in "Chuck Versus the First Fight", designed to render the Intersect images in Chuck's head inaccessible, and thus prevent them affecting his life.
Whilst Chuck is in his father's base attempting to get the Phalanx XR-12 computer to read a SIS disk supposedly containing evidence of his mother's innocence, Mary takes the device from a storage box labelled "Eurybia". She then powers up the device and displays it to Chuck, as blue intersect suppression images flash up as a video stream. This causes Chuck's Intersect 2.0 to become inaccessible, preventing him from flashing until "Chuck Versus the Leftovers", when he regains this ability, through a laptop left by his father.
In "Chuck Versus the Fear of Death", Chuck undergoes a month of intensive assessment and treatment designed to access the Intersect 2.0 and allow Chuck to flash once more. The CIA scientists conducting the assessment concluded that the device hadn't damaged or removed the Intersect but merely suppressed it resulting in Chuck being unable to flash. After therapy Chuck flashes multiple times, but the contents of the flash are static.
- The suppression device is clearly a modified Sony Playstation Portable, notable for its distinctive shape and shoulder buttons. However, the device has a different faceplate and input panel.